Multiple Myeloma

The Basics

Written by the doctors and editors at UpToDate пїЅ пїЅ

What is multiple myeloma? " пїЅ Multiple myeloma is a cancer of 1 type of white blood cell. White blood cells fight infections in the body. They are made in the bone marrow, which is the middle part of bones. When people have multiple myeloma, the bone marrow makes too many of these white blood cells and not enough of the normal blood cells a persons body needs. This can cause symptoms. пїЅ пїЅ

What are the symptoms of multiple myeloma? " пїЅ Multiple myeloma can cause many different symptoms. These include: пїЅ пїЅ

Bone pain or bones that break easily
Nausea, vomiting, confusion, or feeling more thirsty than usual
Feeling more weak, tired, or short of breath than usual
Blurry vision
Numbness, tingling, or weakness in the chest, lower back, or legs
Getting sick more easily
Losing weight without trying to

All of these symptoms can also be caused by conditions that are not multiple myeloma. But if you have these symptoms, let your doctor or nurse know. пїЅ пїЅ

Sometimes, symptoms of multiple myeloma can be a medical emergency. For example, it is an emergency if multiple myeloma cells or pieces of broken bone push down on a person's spinal cord. The spinal cord is the group of nerves that runs down a person's back. See a doctor immediately if you have: пїЅ пїЅ

Severe back pain
Weakness, numbness, or tingling in the legs
No control over your bladder or bowel (that is a new problem)

Is there a test for multiple myeloma? " пїЅ Yes. Your doctor or nurse will do an exam and tests. Tests can include: пїЅ пїЅ

Blood or urine tests
Bone marrow biopsy " пїЅ A doctor will take a very small sample of the bone marrow. Another doctor will look at the sample under a microscope to see if cancer cells are present.
X-ray or other imaging tests " пїЅ Imaging tests create pictures of the inside of the body.

How is multiple myeloma treated? " пїЅ People with multiple myeloma often have 1 or more of the following treatments: пїЅ пїЅ

"Watch and wait " пїЅ " пїЅ Some people have a condition called "smoldering myeloma " пїЅ before they get multiple myeloma. These people do not have any symptoms and might not receive treatment right away. But their doctor does follow them. When they start to have symptoms, they will have active treatment.
Chemotherapy " пїЅ Chemotherapy is the term doctors use to describe a group of medicines that kill cancer cells.
Steroid medicines " пїЅ These medicines can kill cancer cells and slow cancer growth. (These steroids are not the same steroids that athletes take to build muscle.)
Medicines called "immune modulating medicines " пїЅ " пїЅ These medicines stop the cancer from growing.
Bone marrow transplant " пїЅ The bone marrow makes blood cells, including white blood cells. During a bone marrow transplant, a doctor removes some bone marrow from the body. Then, the person gets medicines called "chemotherapy. " пїЅ These medicines are usually used to kill cancer cells, but they also kill bone marrow cells. After chemotherapy, the doctor puts the bone marrow back into the person's body.

People with multiple myelomaalso have treatment for any symptoms they have. For example, doctors might treat bone symptoms with pain medicines, medicines to stop bone loss, or radiation therapy. Radiation can kill cancer cells. пїЅ пїЅ

What happens after treatment? " пїЅ After treatment, you will be checked every so often to see if the cancer comes back. Treatment does not usually cure the disease, but it can reduce symptoms andhelp people live longer. Follow-up tests can include blood tests, urine tests, imaging tests, or bone marrow biopsy. пїЅ пїЅ

What happens if the multiple myeloma comes back? " пїЅ If the multiple myeloma comes back, you might get more chemotherapy, immune modulating medicines, steroid medicines, or bone marrow transplant. пїЅ пїЅ

What else should I do? " пїЅ It is important to follow all your doctors ' instructions about visits and tests. It's also important to talk to your doctor about any side effects or problems you have during treatment. пїЅ пїЅ

Getting treated for multiple myeloma involves making many choices, such as what treatment to have and when. Always let your doctors and nurses know how you feel about a treatment. Any time you are offered a treatment, ask: пїЅ пїЅ

What are the benefits of this treatment? Is it likely to help me live longer? Will it reduce or prevent symptoms?
What are the downsides to this treatment?
Are there other options besides this treatment?
What happens if I do not have this treatment?

All topics are updated as new evidence becomes available and our peer review process is complete. пїЅ пїЅ

This topic retrieved from UpToDate on: Nov 04, 2014. пїЅ пїЅ

Topic 15531 Version 5.0 пїЅ пїЅ

Release: 22.8 - C22.206 пїЅ пїЅ

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Multiple Myeloma

The Basics

Consumer Information Use and Disclaimer

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