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Red Cell Distribution Width (RDW)


Definition


  • RDW is a coefficient of variation of the distribution of individual RBC volume.
  • Normal range: 12.1 " “14 fL.

Use


  • An elevation in RDW is useful in drawing attention to anisocytosis, a marker for various anemias.

Interpretation


  • The RDW is particularly helpful in separating iron deficiency anemia (high RDW, normal to low MCV) from Ž ²-thalassemia trait (normal RDW, low MCV).
  • Increased RDW is also useful in identifying red cell fragmentation, agglutination, or dimorphic cell populations.

Limitations


  • Very high WBC, numerous large platelets, and autoagglutination result in falsely elevated RDW.
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