Plasminogen Activator Inhibitor 1 (PAI 1)

Doctor123.org helps physicians and healthcare professionals Diseases & Conditions Drugs Patient Handouts Procedures Lab Tests Plasminogen Activator Inhibitor 1 (PAI 1) Definition PAI 1, an inhibitor of plasminogen activation is synthesized in endothelial cells, in platelets, and by the liver. Normal range: 0.0 " “22.0 IU/mL. Use This test may be used in rare cases with a tendency to thrombosis when no other cause is identified. Interpretation Decreased Values Difficult to determine because the normal range can be as low as 0.0 Cases with an increased fibrinolytic tendency (bleeding, rapid dissolution of hemostatic clots) Increased Values May result in a tendency to arterial or venous thrombosis Acquired: during acute thrombotic episodes, pregnancy, sepsis Congenital: rare congenital elevations have been described Limitations This test is a biologic assay that is difficult to perform reproducibly. The inhibitor has diurnal variations, with highest levels during morning hours (blood should be drawn fasting between 8 am and 12 pm). Copyright © 2016 - 2017 Doctor123.org | Disclaimer