Mean Platelet Volume (MPV)

MPV reflects the frequency distribution of platelet volumes.

Normal range: 7.8 " “11.0 fL.

Use

MPV is used to evaluate variations in platelet size as related to various platelet abnormalities.

Interpretation

Increased In

Hypothyroidism

Myeloproliferative neoplasms

All cases of accelerated bone marrow production of platelets (immune thrombocytopenias, postchemotherapy)

Bernard-Soulier syndrome

Decreased In

Disorders associated with decreased platelet production

In some patients with sepsis

In some patients with inherited thrombocytopenias, such as Wiskott-Aldrich syndrome

Limitations

Reference values appear to vary with the platelet count. MPV is affected by numerous variables related to specimen collection, the anticoagulant used, temperature, and duration of storage.