Lipase

Doctor123.org helps physicians and healthcare professionals Diseases & Conditions Drugs Patient Handouts Procedures Lab Tests Lipase Definition Glycoprotein enzyme filtered by glomeruli and completely reabsorbed by proximal tubules; method should always include colipase in reagent Normal range: 0 " “50 U/L Use Investigating pancreatic disorders, usually pancreatitis More specific for pancreatitis than is for serum amylase; diagnosis of peritonitis, strangulated or infarcted bowel, pancreatic cyst Interpretation Increased In Acute pancreatitis Perforated or penetrating peptic ulcer, especially with involvement of the pancreas Obstruction of pancreatic duct by Stone Drug-induced spasm of sphincter of Oddi (e.g., codeine, morphine, meperidine, methacholine, cholinergics) to levels 2 " “15 times normal Partial obstruction plus drug stimulation Chronic pancreatitis Acute cholecystitis Small bowel obstruction Intestinal infarction Acute and chronic renal failure (increased two to three times in 80% of patients and five times in 5% of patients) Organ transplant (kidney, liver, heart), especially with complications (e.g., organ rejection, CMV infection, cyclosporin toxicity) Alcoholism DKA After ERCP Some cases of intracranial bleeding (unknown mechanism) Macro forms in lymphoma, cirrhosis Drugs Induced acute pancreatitis (see preceding section on serum amylase) Cholestatic effect (e.g., indomethacin) Methodologic interference (e.g., pancreozymin [contains lipase], deoxycholate, glycocholate, taurocholate [prevent inactivation of enzyme], bilirubin [turbidimetric methods]) Chronic liver disease (e.g., cirrhosis) (usually ≤2 times normal) Decreased In Methodologic interference (e.g., presence of Hb, quinine, heavy metals, calcium ions) Normal In Mumps Macroamylasemia Lower value in neonates Limitations Certain drugs such as cholinergics and opiates may elevate serum lipase. Renal disease may elevate the serum lipase. Copyright © 2016 - 2017 Doctor123.org | Disclaimer