Factor XIII

Factor XIII is synthesized in the liver and also present in high concentrations in platelets. Factor XIII is a plasma transglutaminase proenzyme activated by thrombin in the presence of calcium. It promotes clot stability by forming intermolecular covalent bonds between fibrin monomers.

Normal range: reported qualitatively as normal or decreased; quantitation performed in reference laboratories.

Use

Factor XIII values are decreased in factor XIII deficiency, which can be either inherited or acquired.

Interpretation

Decreased In

Inherited deficiency

AML

Liver disease

Association with hypofibrinogenemia in obstetric complications such as DIC