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Ceruloplasmin


Definition


  • Major copper-carrying protein in the blood. Anα-2 globulin, it plays a role in both iron and copper metabolism. Other names: CP, ferroxidase, iron(II):oxygen oxidoreductase.
  • Normal range: 22 " “58 mg/dL.

Use


  • Evaluation of acute-phase response
  • Assessment of possible Wilson disease
  • Assessment of Menkes kinky hair syndrome, aceruloplasminemia

Interpretation


Increased In


  • Inflammation, infection (acute and chronic), tissue injury
  • Cardiovascular disease
  • Pregnancy (double the baseline values in third trimester)
  • Cancer
  • Cirrhosis
  • Estrogen supplementation and oral contraceptives
  • RA
  • Primary sclerosing cholangitis
  • Alzheimer disease
  • Use of birth control pills

Decreased In


  • Hepatolenticular degeneration (Wilson disease)
  • Autosomal recessive disease involving copper metabolism
  • Kwashiorkor, malabsorption
  • Nephrosis, nephritic syndrome
  • Menkes kinky hair syndrome
  • Aceruloplasminemia

Limitations


  • Anticonvulsant therapy, methadone, tamoxifen, oral contraceptives, and smoking increase serum levels.
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