Acetaminophen (N-Acetyl-p-Aminophenol; APAP)

Doctor123.org helps physicians and healthcare professionals Diseases & Conditions Drugs Patient Handouts Procedures Lab Tests Acetaminophen (N-Acetyl-p-Aminophenol; APAP) Definition Nonopioid analgesic, antipyretic Use Relief of pain, such as headaches and toothaches Reduction of fever Interpretation Screen of urine: indication of exposure Screen of serum: used to assess potential toxicity Normal range: 5 " “20 Ž ¼g/mL serum Potentially toxic: >150 Ž ¼g/mL measured 4 hours postdose Limitations Screening Serum/urine: colorimetric or immunoassay on automated chemistry analyzers High bilirubin concentrations [>50 Ž ¼g/mL] may cause false-positive results with immunoassay-based tests. Plasma may be tested in place of serum. Anticoagulants such as EDTA and heparin do not generally interfere with the assay. Do not use whole blood. Confirmation: Serum/urine " “HPLC or GC/MC APAP is highly conjugated by glucuronidation and sulfation. An assay that includes a hydrolysis step provides total APAP levels, which are not useful for assessing toxicity. Copyright © 2016 - 2017 Doctor123.org | Disclaimer