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Nonsteroidal Antiinflammatory Drugs (NSAIDs)

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  • Blood thinners, such as warfarin (brand name: Coumadin) or heparin
  • Phenytoin (brand names: Dilantin, Phenytek), a medicine used to prevent seizures
  • Cyclosporine, a medicine given to people who have had an organ transplant

  • What side effects can NSAIDs cause? " ” In most cases, NSAIDs cause no side effects. The side effects they do cause can include: ‚  
    • Stomach upset, ulcers, and bleeding " “ NSAIDs can cause stomach upset. If you take them regularly for a long time, NSAIDs can also cause ulcers or bleeding in the stomach or intestines.
    • Liver damage " “ Long-term use of NSAIDs, especially at high doses, can harm the liver.
    • Kidney damage " “ Using NSAIDs, even for a short time, can harm the kidneys. They are especially risky in people who already have kidney disease.
    • Ringing in the ears " “ Ringing in the ears (tinnitus) is common in people who take high doses of aspirin. It can also happen in people who take other NSAIDs. The ringing usually goes away when they take a lower dose.

    What happens if I take more than the recommended dose? " ” Taking more than the recommended dose of an NSAID might not cause serious problems. But it could make side effects much more likely without helping your symptoms very much. On the other hand, taking too much aspirin or acetaminophen (sample brand name: Tylenol) can be harmful or even cause death. ‚  
    Anybody who takes too much of any medicine at once should call a doctor or the Poison Control Hotline (1-800-222-1222). If the person is not breathing or is not conscious, call for an ambulance (in the US and Canada, dial 9-1-1). ‚  
    All topics are updated as new evidence becomes available and our peer review process is complete. ‚  
    This topic retrieved from UpToDate on: Nov 04, 2014. ‚  
    Topic 16268 Version 8.0 ‚  
    Release: 22.8 - C22.208 ‚  
    ‚ © 2014 UpToDate, Inc. All rights reserved. ‚  

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    This information is not specific medical advice and does not replace information you receive from your health care provider. This is only a brief summary of general information. It does NOT include all information about conditions, illnesses, injuries, tests, procedures, treatments, therapies, discharge instructions or life-style choices that may apply to you. You must talk with your health care provider for complete information about your health and treatment options. This information should not be used to decide whether or not to accept your health care providers advice, instructions or recommendations. Only your health care provider has the knowledge and training to provide advice that is right for you.The use of UpToDate content is governed by the UpToDate Terms of Use. ‚ ©2014 UpToDate, Inc. All rights reserved. ‚  

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