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Amphetamines


Definition


  • Sympathomimetic amines with central nervous system stimulant activity.
  • Other names: amphetamine (Adderall, Dexedrine, Benzedrine, "bennies " �), methamphetamine (Desoxyn, "ice, " � "speed, " � "meth " �), ecstasy (3,4-methylenedioxymethamphetamine; MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxyethylamphetamine (MDEA, MDE, "Eve " �), pseudoephedrine (Sudafed), ephedrine, phentermine (Adipex), and methylphenidate (Ritalin).
  • Other psychotropic amines include 4-bromo-2,5-dimethoxyamphetamine, p-methoxyamphetamine (PMA), and p-methoxymethamphetamine (PMMA). These are not generally detected in screening tests and may not be reported in confirmation tests unless specifically requested.
  • Other drugs that are metabolized to methamphetamine/amphetamine: benzphetamine, clobenzorex, famprofazone, fenethylline, and fenproporex.

Use


  • Appetite suppressants
  • Mood enhancers (psychotropics)
  • Treatment of attention deficit hyperactivity disorder
  • Nasal decongestants, bronchodilators

Limitations


  • Screen [urine]: immunoassay on automated chemistry analyzers
    • Amphetamine: Generally do not give positive results for l-amphetamine, MDA, MDMA, ephedrine, phentermine.
    • Ecstasy: The target analyte of most immunoassays is MDMA. Screen will not give positive results with d/l-amphetamine, d/l-methamphetamine, phentermine, ephedrine, pseudoephedrine, PMA, PMMA.
  • Screen [serum]: ELISA
    • Target analyte: d-amphetamine. Will not give positive results with l-amphetamine, l-methamphetamine, phenylpropanolamine, MDMA, MDE.
    • May produce positive results with MDA.
  • Confirmation [serum/urine]:
    • Confirmation techniques do not typically differentiate between d and l forms of amphetamine and methamphetamine.
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