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  • 11-Deoxycortisol, also known as cortodoxone, corticosterone, and compound S, is a steroid and an immediate precursor to the production of cortisol. It can be synthesized from 17-hydroxyprogesterone. Excretion in urine is included in 17-ketogenic steroid (17-KGS) and Porter-Silber 17-OHKS measurements, which were originally used to provide some measure of cortisol production. The direct measurement of cortisol has replaced determinations of 17-KS and 17-OHKS.

  • Normal range: <50 ng/dL in males; <33 ng/dL in females.


  • Diagnosis of and monitoring therapeutic response in CAH due to 11 Ž ²-hydroxylase deficiency

  • Assessment of adrenal response in the metyrapone test; result after metyrapone stimulation is >8,000 ng/dL


Increased In

  • Values are increased in CAH (P450cII deficiency) and following metyrapone administration in normal persons.

Decreased In

  • Values are decreased in adrenal insufficiency.


  • Patients with myxedema, some pregnant patients, and those on oral contraceptives respond poorly during the test.

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