(ta va BOR ole)
Onychomycosis: Topical treatment of onychomycosis of the toenail(s) due to Trichophyton rubrum and Trichophyton mentagrophytes
There are no contraindications listed in the manufacturer 's labeling.
Onychomycosis: Topical: Apply to affected toenail(s) once daily for 48 weeks.
Refer to adult dosing.
There are no dosage adjustments provided in the manufacturers labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturers labeling. However, dosage adjustment unlikely due to low systemic absorption.
Topical: Affected toenails should be clean and dry. Apply to completely cover affected toenail surface using provided dropper; also apply under the tip of each affected toenail. Avoid contact with skin other than skin surrounding the treated toenails; wipe away excess solution from surrounding skin and allow solution to dry. Wash hands with soap and water after application.
Store at 20 ‚ °C to 25 ‚ °C (68 ‚ °F to 77 ‚ °F); excursions permitted to 15 ‚ °C to 30 ‚ °C (59 ‚ °F to 86 ‚ °F). Keep away from heat or flame. Discard bottle within 3 months of insertion of the dropper.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, External:
Kerydin: 5% (4 mL, 10 mL) [contains edetate calcium disodium, propylene glycol]
There are no known significant interactions.
1% to 10%:
Dermatologic: Ingrown nail (3%)
Local: Local skin exfoliation (3%), application site erythema (2%), application site dermatitis (1%)
Concerns related to adverse events:
- Local irritation: Persistent local irritation, erythema, exfoliation, or dermatitis may develop; instruct the patient to contact their health care provider if this occurs.
Other warnings/precautions:
- Appropriate use: For topical use only; avoid contact with eyes or mucous membranes. Avoid contact with skin (other than skin immediately surrounding treated toenail).
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Adverse events were observed in some animal reproduction studies.
Tavaborole is an oxaborole antifungal that inhibits fungal protein synthesis by inhibition of an aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS).
Extensive
Urine
- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
- Have patient report immediately to prescriber severe application site irritation or ingrown toenail (HCAHPS).
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.