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Bacitracin and Polymyxin B (Topical)


General


Pronunciation

(bas i TRAY sin & pol i MIKS in bee)


Brand Names: U.S.

  • Double Antibiotic [OTC]
  • Polysporin [OTC]

Indications


Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns


Contraindications


Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation


Dosing and Administration


Dosing: Adult

Topical infection prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.


Dosing: Geriatric

Refer to adult dosing.


Dosing: Pediatric

Topical infection prevention: Children and Adolescents: Refer to adult dosing.


Administration

Topical: Do not use topical ointment in the eyes; avoid contact of tube tip with skin.


Dosage Forms/Strengths


Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Double Antibiotic: 500-10000 UNIT/GM (1 ea, 14.17 g, 28.35 g)

Polysporin: 500-10000 UNIT/GM (1 ea, 14.2 g, 28.3 g)


Drug Interactions

There are no known significant interactions.


Adverse Reactions


See individual agents.


Warnings/Precautions


Pregnancy Risk Factor

C


Pregnancy Considerations

Animal reproduction studies have not been conducted with this combination.


Actions


Pharmacology

See individual agents.


Absorption

Insignificant from intact skin or mucous membrane


Patient and Family Education


Patient Education

- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

- Patient may experience burning or itching. Have patient report immediately to prescriber edema or severe skin irritation (HCAHPS).

- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

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