Chronic Granulomatous Disease

- Pneumonia " пїЅ This is a lung infection that causes coughing, fever, and trouble breathing. People with CGD can get pneumonia many times. - Skin infections " пїЅ These include: - Cellulitis, a skin infection that causes redness, pain, and swelling - Impetigo, a skin infection that causes red bumps on the skin

CGD here) is a serious disease that causes infections, inflammation, and other symptoms. In a person who has CGD, some of the cells that normally fight infection do not work correctly. This makes the person likely to get many infections. These infections can be very serious. Sometimes, they even cause death. пїЅ пїЅ

CGD is a rare disease. It runs in families. Because CGD causes so many infections, doctors usually find it when the person with CGD is a child. CGD is more common in boys, but girls can also get it. пїЅ пїЅ

What are the symptoms of CGD? " пїЅ The symptoms include: пїЅ пїЅ

Pneumonia " пїЅ This is a lung infection that causes coughing, fever, and trouble breathing. People with CGD can get pneumonia many times.
Skin infections " пїЅ These include:Cellulitis, a skin infection that causes redness, pain, and swellingImpetigo, a skin infection that causes red bumps on the skin
Swollen lymph nodes " пїЅ These are bean-shaped organs that are part of the bodys infection-fighting system. There are lymph nodes behind the ears, in the neck, and in many other areas of the body. If a person is sick, lymph nodes can swell up and hurt.
Abscesses " пїЅ Swollen, red, and painful areas on the skin. A common place to get these is around the rectum.
Growth problems " пїЅ A child with CGD might be smaller than other children the same age.

People with CGD might not have symptoms, such as a fever, even if they have severe infections. They often have infections that come back again and again. For example, a child with CGD might get pneumonia several times. Or he or she might have many skin infections. пїЅ пїЅ

Is there a test for CGD? " пїЅ Yes. The doctor or nurse will ask about your child's symptoms and do an exam. He or she will order blood tests. The tests can show: пїЅ пїЅ

Problems with the body's infection-fighting system " пїЅ This is also called the "immune system. " пїЅ In people who have CGD, some of the cells in the immune system do not work correctly.
Abnormal genes " пїЅ People with CGD have abnormal genes. A type of blood test called a "genetic test" can show if the genes are abnormal. If they are, this is good proof of CGD.

If someone in your family had CGD, your child should have a blood test soon after he or she is born. If you are pregnant and know someone in your family had CGD, you can have tests before your baby is born. These tests can show if the baby has CGD. If doctors find CGD before a baby is born, they can make plans to prevent infections and treat the disease. пїЅ пїЅ

How is CGD treated? " пїЅ Treatments include: пїЅ пїЅ

Medicines " пїЅ These can:Help prevent infectionTreat any infections that happen
Bone marrow transplant " пїЅ This treatment can cure CGD. A bone marrow transplant is a procedure that replaces abnormal or missing cells in the bone marrow with healthy cells. The bone marrow is the tissue in the middle of certain bones. Bone marrow makes blood cells.

If a person with CGD gets a transplant of healthy bone marrow, this can help his or her body make new blood cells. The new blood cells from the transplant include normal infection-fighting cells. If a bone marrow transplant works, a person who had CGD can fight off infections like a healthy person. пїЅ пїЅ

All topics are updated as new evidence becomes available and our peer review process is complete. пїЅ пїЅ

This topic retrieved from UpToDate on: Nov 04, 2014. пїЅ пїЅ

Topic 83030 Version 3.0 пїЅ пїЅ

Release: 22.8 - C22.208 пїЅ пїЅ

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Chronic Granulomatous Disease

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