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Theophylline (1,3-Dimethylxanthine)


Definition


  • A naturally occurring (tea) xanthine derivative with diuretic, cardiac stimulant, and smooth muscle relaxant properties. Other names: Theo-Dur, Uniphyl, Slo-bid, and Theolair.
  • Normal range:
    • 0 " “5 months: 6 " “12 Ž ¼g/mL
    • Greater than 6 months: 10 " “20 Ž ¼g/mL

Use


  • As a bronchodilator to prevent and treat asthma

Interpretation


  • Potentially toxic: 20 " “25 Ž ¼g/mL

Limitations


  • Serum: Quantitative immunoassay limitations
    • FPIA, chemiluminescence, EMIT, particle-enhanced turbidimetric inhibition immunoassay.
    • Do not use serum separator tubes or gels. Separate serum from cells as soon as possible.
    • The incidence of patients having antibodies to Escherichia coli Ž ²-galactosidase is extremely low. However, some samples containing such antibodies may result in artificially high results that do not fit the clinical profile.
    • Due to cross-reactivity with 1,3-dimethyluric acid (metabolite), the assay should not be used to quantitate samples from uremic patients.
    • If mouse antibodies are utilized, the possibility exists for interference by human antimouse antibodies (HAMA) in the sample, which could cause falsely elevated results.
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