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Poly-Ureaurethane


General


Pronunciation

(pol ee yoor EE a URE e thane)


Brand Names: U.S.

  • Nuvail ¢ „ ¢

Indications


Use: Labeled Indications

Management of symptoms of nail dystrophy (nail splitting, nail fragility)


Contraindications


Use with deep, open, or profusely bleeding wounds


Dosing and Administration


Dosing: Adult

Nail dystrophy: Topical: Apply once daily before bedtime to affected nail(s)


Dosing: Geriatric

Refer to adult dosing.


Administration

Apply evenly to affected nail plate, proximal and lateral folds, and distal tip; allow to dry completely. Clean affected nails with nail polish remover once weekly. Use of other topical products before application of poly-ureaurethane may prevent film formation and reduce effectiveness. To avoid staining, avoid contact with finished surfaces (eg, furniture, counter tops).


Storage

Store at 15 ‚ °C to 30 ‚ °C (59 ‚ °F to 86 ‚ °F); avoid excessive heat and humidity. Flammable liquid; keep away from heat and flame; use in well-ventilated area.


Dosage Forms/Strengths


Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, topical:

Nuvail ¢ „ ¢: 16% (15 mL)


Drug Interactions

There are no known significant interactions.


Adverse Reactions


Frequency not defined: Dermatologic: Dermal irritation/stinging


Warnings/Precautions


Concerns related to adverse effects:

- Skin irritation: May sting upon application; discontinue use if redness or other signs of irritation occur.

Special populations:

- Isocyanate sensitization: Patients sensitized to isocyanate should not use poly-ureaurethane.

Other warnings/precautions:

- Flammable: Formulation is flammable; do not expose to high temperatures or near open flame. Use in a well-ventilated area.


Actions


Pharmacology

Biocompatible, polymeric solution; forms uniform film that protects nail from abrasion, friction, and moisture


Patient and Family Education


Patient Education

- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

- Patient may experience stinging. Have patient report immediately to prescriber severe skin irritation.

- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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