(nye STAT in)
Treatment of susceptible cutaneous, mucocutaneous, and oral cavity fungal infections normally caused by the Candida species
Hypersensitivity to nystatin or any component of the formulation
Oral candidiasis: Suspension (swish and swallow): 400,000-600,000 units 4 times/day; swish in the mouth and retain for as long as possible (several minutes) before swallowing
Intestinal infections: Oral tablets: 500,000-1,000,000 units every 8 hours
Note: Powder for compounding: 1/8 teaspoon (500,000 units) to equal approximately 1/2 cup of water; give 4 times/day
Refer to adult dosing.
Oral candidiasis:
Suspension:
Premature infants: 100,000 units 4 times/day; paint suspension into recesses of the mouth
Infants: 200,000 units 4 times/day or 100,000 units to each side of mouth 4 times/day; paint suspension into recesses of the mouth
Children: 400,000-600,000 units 4 times/day; swish in the mouth and retain for as long as possible (several minutes) before swallowing
Powder for compounding: Children: Refer to adult dosing.
No dosage adjustment provided in manufacturer 's labeling.
No dosage adjustment provided in manufacturer 's labeling.
Suspension: Shake well before using. Should be swished about the mouth and retained in the mouth for as long as possible (several minutes) before swallowing. For neonates and infants, paint nystatin suspension into recesses of the mouth.
Tablet and suspension: Store at controlled room temperature of 15 ‚ °C to 25 ‚ °C (59 ‚ °F to 77 ‚ °F).
Powder for suspension: Store under refrigeration at 2 ‚ °C to 8 ‚ °C (36 ‚ °F to 46 ‚ °F).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Capsule, Oral [preservative free]:
Bio-Statin: 500,000 units, 1,000,000 units [dye free]
Powder, Oral:
Bio-Statin: (1 ea)
Generic: (1 ea)
Suspension, Mouth/Throat:
Generic: 100,000 units/mL (5 mL, 60 mL, 473 mL, 480 mL)
Tablet, Oral:
Generic: 500,000 units
Saccharomyces boulardii: Antifungal Agents (Systemic, Oral) may diminish the therapeutic effect of Saccharomyces boulardii. Avoid combination
1% to 10%: Gastrointestinal: Diarrhea, nausea, stomach pain, vomiting
<1% (Limited to important or life-threatening): Hypersensitivity reactions
C
Animal reproduction studies have not been conducted. Adverse events in the fetus or newborn have not been reported following maternal use of vaginal nystatin during pregnancy. Absorption following oral use is poor.
Binds to sterols in fungal cell membrane, changing the cell wall permeability allowing for leakage of cellular contents
Poorly absorbed
Feces (as unchanged drug)
Symptomatic relief from candidiasis: 24-72 hours
- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
- Patient may experience abdominal pain, nausea, vomiting, or diarrhea. Have patient report immediately to prescriber severe dysphagia or severe mouth pain or irritation (HCAHPS).
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.