(ep i NAS teen)
Treatment of allergic conjunctivitis
There are no contraindications listed in the manufacturers labeling.
Allergic conjunctivitis: Ophthalmic: Instill 1 drop into each eye twice daily. Continue throughout period of exposure, even in the absence of symptoms.
Refer to adult dosing.
Allergic conjunctivitis: Ophthalmic: Children ≥2 years: Refer to adult dosing.
No dosage adjustment provided in manufacturers labeling. However, dosage adjustment unlikely due to low systemic absorption.
No dosage adjustment provided in manufacturers labeling. However, dosage adjustment unlikely due to low systemic absorption.
For ophthalmic use only; avoid touching tip of applicator to eye or other surfaces. Contact lenses should be removed prior to application, may be reinserted after 10 minutes. Do not wear contact lenses if eyes are red.
Store at controlled room temperature of 15 ‚ °C to 25 ‚ °C (59 ‚ °F to 77 ‚ °F). Keep tightly closed.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic, as hydrochloride:
Elestat: 0.05% (5 mL) [contains benzalkonium chloride]
Generic: 0.05% (5 mL)
There are no known significant interactions.
Frequency not always defined.
1% to 10%:
Central nervous system: Headache (1% to 3%)
Infection: Infection (10%; defined as cold symptoms and upper respiratory tract infection)
Ophthalmic: Burning sensation of eyes, eye pruritus, follicular conjunctivitis, ocular hyperemia
Respiratory: Cough (1% to 3%), pharyngitis (1% to 3%), rhinitis (1% to 3%), sinusitis (1% to 3%)
<1% (Limited to important or life-threatening): Increased lacrimation
Concerns related to adverse effects:
- Bacterial keratitis: Inadvertent contamination of multiple-dose ophthalmic solutions has caused bacterial keratitis.
Special populations:
- Contact lens wearers: Contains benzalkonium chloride which may be absorbed by contact lenses; remove contact lenses prior to use and wait 10 minutes before reinserting.
Other warnings/precautions:
- Appropriate use: For topical ophthalmic use only. Not for the treatment of contact lens irritation; do not wear contact lenses if eye is red.
C
Teratogenic effects were not observed in animal studies. There are no adequate and well-controlled studies in pregnant women.
Selective H1-receptor antagonist; inhibits release of histamine from the mast cell; also has affinity for the H2, alpha1, alpha2, and the 5-HT2 receptors
Low systemic absorption following topical application
Does not cross blood-brain barrier
<10% metabolized
IV: Urine (55%); feces (30%)
3-5 minutes
8 hours
12 hours
64%
- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
- Patient may experience stinging, burning, cough, eye infection, or rhinorrhea. Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.