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Cromolyn (Ophthalmic)


General


Pronunciation

(KROE moe lin)


Indications


Use: Labeled Indications

Treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis


Contraindications


Hypersensitivity to cromolyn or any component of the formulation


Dosing and Administration


Dosing: Adult

Conjunctivitis and keratitis: Ophthalmic: 1-2 drops in each eye 4-6 times/day


Dosing: Geriatric

Refer to adult dosing.


Dosing: Pediatric

Conjunctivitis and keratitis: Ophthalmic: Children >4 years: Refer to adult dosing.


Dosing: Renal Impairment

No dosage adjustment provided in manufacturer 's labeling. However, dosage adjustment unlikely due to low systemic absorption.


Dosing: Hepatic Impairment

No dosage adjustment provided in manufacturer 's labeling. However, dosage adjustment unlikely due to low systemic absorption.


Storage

Store at room temperature of 15 ‚ °C to 30 ‚ °C (59 ‚ °F to 86 ‚ °F). Protect from light.


Dosage Forms/Strengths


Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic, as sodium:

Generic: 4% (10 mL)


Drug Interactions

There are no known significant interactions.


Adverse Reactions


Frequency not defined.

Ocular: Conjunctival injection, dryness around the eye, edema, eye irritation, immediate hypersensitivity reactions, itchy eyes, puffy eyes, styes, rash, watery eyes

Respiratory: Dyspnea


Warnings/Precautions


Concerns related to adverse effects:

- Anaphylaxis: Severe anaphylactic reactions may occur rarely

Dosage form specific issues:

- Ophthalmic: Transient burning or stinging may occur with ophthalmic use.

Other warnings/precautions:

- Appropriate use: Prophylactic drug with no benefit for acute situations.

- Withdrawal: Caution should be used when withdrawing the drug or tapering the dose as symptoms may reoccur.


Pregnancy Risk Factor

B


Pregnancy Considerations

Adverse events were not observed in animal reproduction studies.


Actions


Absorption

~0.03%


Excretion

Urine and feces (equal amounts as unchanged drug); exhaled gases (small amounts)


Onset of Action

Response to treatment: May be seen within a few days; treatment for up to 6 weeks is often required


Half-Life Elimination

80-90 minutes


Patient and Family Education


Patient Education

- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

- Patient may experience stinging or burning. Have patient report immediately to prescriber shortness of breath, vision changes, eye pain, severe eye irritation, or eye discharge (HCAHPS).

- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

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