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Monoclonal Gammopathy of Undetermined Significance


The Basics


Written by the doctors and editors at UpToDate � �
What is monoclonal gammopathy of undetermined significance? " � Monoclonal gammopathy of undetermined significance, called "MGUS " � for short, is a condition that involves 1 type of white blood cell. White blood cells fight infections in the body. They are made in the bone marrow, which is the middle part of bones. � �
When people have MGUS, their bone marrow makes too many of 1 type of white blood cell. These white blood cells make a protein called monoclonal protein (M-protein). � �
MGUS causes no symptoms and, in most cases, does not lead to any problems. But in some cases, MGUS can turn into a serious condition. One serious condition is multiple myeloma, which is a cancer of the white blood cells involved in MGUS. � �
What are the symptoms of MGUS? " � MGUS does not cause any symptoms. Your doctor or nurse will suspect you have it after you have lab tests done for another reason. � �
Is there a test for MGUS? " � Yes. If your doctor or nurse suspects you have MGUS from other lab test results, he or she will do an exam and further tests. These can include: � �
  • Blood tests
  • Urine tests
  • A bone marrow biopsy " � For this test, a doctor takes a very small sample of the bone marrow. Then another doctor looks at the sample under a microscope to see which cells are present.
  • Imaging tests, such as X-rays, CT scans, or MRI scans " � Imaging tests create pictures of the inside of the body.

How is MGUS treated? " � MGUS does not need treatment. But your doctor will monitor your condition closely. That way, he or she will know if your MGUS turns into a serious condition that does need treatment. � �
To monitor your condition, your doctor will talk with you and do exams on a regular basis. He or she might also order repeat blood and urine tests. How often these tests are done depends on your individual situation. � �
People with MGUS have a higher-than-normal chance of breaking a bone. Because of this, your doctor will check you for osteoporosis, a disease that makes your bones weak. If you have osteoporosis, he or she will treat it. If you dont have osteoporosis, your doctor will recommend things you can do to help keep your bones strong. This includes getting enough calcium and vitamin D. � �
What symptoms should I watch for? " � You should watch for symptoms that could mean your MGUS has changed into a serious condition. This change can happen quickly. Let your doctor or nurse know right away if you have any of the following symptoms: � �
  • Bone pain
  • Feeling more tired or weak than usual
  • Fever
  • Night sweats that soak your clothes
  • Headache or dizziness
  • Weight loss
  • Numbness, tingling, or weakness in the chest, lower back, or legs
  • Blurry vision or trouble hearing
  • Bleeding more than usual

These symptoms can also be caused by other conditions that are not serious. But your doctor or nurse will want to check that your MGUS hasn't changed into a condition that needs treatment. � �
All topics are updated as new evidence becomes available and our peer review process is complete. � �
This topic retrieved from UpToDate on: Nov 04, 2014. � �
Topic 86741 Version 1.0 � �
Release: 22.8 - C22.206 � �
� � 2014 UpToDate, Inc. All rights reserved. � �

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This information is not specific medical advice and does not replace information you receive from your health care provider. This is only a brief summary of general information. It does NOT include all information about conditions, illnesses, injuries, tests, procedures, treatments, therapies, discharge instructions or life-style choices that may apply to you. You must talk with your health care provider for complete information about your health and treatment options. This information should not be used to decide whether or not to accept your health care providers advice, instructions or recommendations. Only your health care provider has the knowledge and training to provide advice that is right for you.The use of UpToDate content is governed by the UpToDate Terms of Use. � �2014 UpToDate, Inc. All rights reserved. � �

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