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Granulomatosis With Polyangiitis (Wegener's)

Wegeners granulomatosis. " � � �
What are the symptoms of granulomatosis with polyangiitis? " � The symptoms include: � �
  • Runny nose " � The discharge from the nose can include pus or blood and does not go away
  • Small sores in the nose or mouth
  • Sinus infections " � The sinuses are hollow areas in the bones of the face
  • Ear problems, including fluid leaking from the ear, ear pain, ear infections, and hearing loss
  • Inflammation and break down of "cartilage " � Cartilage is the tough, elastic tissue found in the ears, the windpipe, and the spaces between bones.
  • A hoarse voice
  • Cough
  • Wheezing and breathing problems
  • Chest pain
  • Blood in the urine
  • Red or purple spots on the skin, most often on the lower legs

Is there a test for granulomatosis with polyangiitis? " � Yes. Your doctor or nurse will ask about your symptoms and do an exam. Other tests include: � �
  • Blood tests
  • Urine tests
  • A X-ray or CT scan (a special type of X-ray) of the chest
  • A biopsy " � This is a test that involves taking a small sample of tissue. A doctor examines the sample in a lab. The tissue is usually taken from the skin or the kidney. Sometimes, the sample is taken from inside the nose or the lungs.

How is granulomatosis with polyangiitis treated? " � The treatment happens in two parts, one after the other. It involves medicines that suppress the body's infection-fighting system, called the "immune system. " � � �
The first part of treatment is called "induction. " � You will need to take strong medicines that are given as pills or into a vein through a small tube called an "IV. " � You will need to see your doctor at least once a month during this part of treatment. That's because the medicines can have serious side effects. This part lasts until your symptoms get better, which usually takes about 6 months. � �
The second part of treatment is called "maintenance. " � For this part, your doctor will switch you to a lower dose of the medicines you are taking. Or you might take different medicines that have less serious side effects. The maintenance part lasts at least one year. � �
All topics are updated as new evidence becomes available and our peer review process is complete. � �
This topic retrieved from UpToDate on: Nov 04, 2014. � �
Topic 83998 Version 2.0 � �
Release: 22.8 - C22.208 � �
� � 2014 UpToDate, Inc. All rights reserved. � �

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