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Mean Platelet Volume (MPV)


Definition


  • MPV reflects the frequency distribution of platelet volumes.
  • Normal range: 7.8 " “11.0 fL.

Use


  • MPV is used to evaluate variations in platelet size as related to various platelet abnormalities.

Interpretation


Increased In


  • Hypothyroidism
  • Myeloproliferative neoplasms
  • All cases of accelerated bone marrow production of platelets (immune thrombocytopenias, postchemotherapy)
  • Bernard-Soulier syndrome

Decreased In


  • Disorders associated with decreased platelet production
  • In some patients with sepsis
  • In some patients with inherited thrombocytopenias, such as Wiskott-Aldrich syndrome

Limitations


  • Reference values appear to vary with the platelet count. MPV is affected by numerous variables related to specimen collection, the anticoagulant used, temperature, and duration of storage.
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