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Anticoagulation DNA Panel


Definition


  • The anticoagulation DNA panel tests for genetic variants in the CYP2C9 and VKORC1 genes that account for >50% of variation in warfarin response. Genotyping may reduce the need for INR surveillance as genotype-based dosing regimens are established.
  • Variants tested by the anticoagulation panel include
    • CYP2C9 *1 (normal)
    • CYP2C9 *2 (c.430C>T; Arg144Cys)
    • CYP2C9 *3 (c.1075A>C; Ile359Leu)
    • VKORC1 *1 (normal)
    • VKORC1 *2 promoter variant (c. " “1639G>A)
  • Normal values:
    • CYP2C9 *1/*1
    • VKORC1 *1/*1

Use


  • Initiating warfarin (Coumadin) therapy
  • Optimizing dosing for warfarin

Limitations


  • The results of a genetic test may be affected by DNA rearrangements, blood transfusion, bone marrow transplantation, or rare sequence variations.
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