(se LEE nee um)
Trace metal supplement
Undiluted administration into peripheral vein
Nutritional supplement:
Oral:
Recommended daily allowance (RDA):
Adults: 55 mcg/day
Pregnancy: 60 mcg/day
Lactation: 70 mcg/day
IV in TPN solutions:
Metabolically stable: 20-40 mcg/day
Deficiency from prolonged TPN support: 100 mcg/day
Refer to adult dosing.
Nutritional supplement:
Oral:
Adequate intake (AI):
1-6 months: 15 mcg/day
7-12 months: 20 mcg/day
Recommended daily allowance (RDA):
1-3 years: 20 mcg/day
4-8 years: 30 mcg/day
9-13 years 40 mcg/day
≥14 years: 55 mcg/day
IV in TPN solutions: 3 mcg/kg/day
Prior to use, store at 20 ‚ °C to 25 ‚ °C (68 ‚ °F to 77 ‚ °F); excursions permitted to 15 ‚ °C to 30 ‚ °C (59 ‚ °F to 86 ‚ °F).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Capsule, Oral:
Selenicaps-200: 200 mcg [corn free, no artificial color(s), rye free, sugar free, wheat free, yeast free]
Capsule, Oral [preservative free]:
Se-100: 100 mcg [dye free, yeast free]
Liquid, Oral:
Aqueous Selenium: 95 mcg/drop (15 mL) [contains sodium benzoate]
Solution, Intravenous:
Generic: 40 mcg/mL (10 mL)
Tablet, Oral:
Oceanic Selenium: 50 mcg, 200 mcg [animal products free, gelatin free, gluten free, kosher certified, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]
Se Aspartate: 50 mcg
Se-Plus Protein: 200 mcg
Selenimin: 125 mcg [corn free, rye free, starch free, sugar free, wheat free]
Selenimin-200: 200 mcg [corn free, rye free, starch free, sugar free, wheat free, yeast free]
Generic: 50 mcg, 200 mcg
Tablet, Oral [preservative free]:
Generic: 50 mcg, 200 mcg
Tablet Extended Release, Oral [preservative free]:
Generic: 200 mcg
Dolutegravir: Selenium may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral selenium. Consider therapy modification
Eltrombopag: Selenium may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any selenium-containing product. Consider therapy modification
Frequency not defined: Local: Irritation
Disease-related concerns:
- Gastrointestinal dysfunction: Use with caution in patients with GI impairment.
- Renal impairment: Use with caution in patients with renal impairment.
Dosage form specific issues:
- Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer 's labeling.
C
Adverse events were seen with high doses in animal studies. Selenium is found in the placenta and cord blood. Teratogenic effects have not been observed with nontoxic doses in humans (IOM, 2000).
Part of glutathione peroxidase which protects cell components from oxidative damage due to peroxidases produced in cellular metabolism
Urine, feces, lungs, skin
- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.