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Potassium P-Aminobenzoate


General


Pronunciation

(poe TASS ee um pe a mee noe BEN zoe ate)


Brand Names: U.S.

  • M2 Potassium [OTC] [DSC]
  • Potaba

Indications


Use: Labeled Indications

Presently, all indications are classified by the FDA as "possibly effective. " �

Treatment of scleroderma, dermatomyositis, morphea, linear scleroderma, pemphigus, Peyronies disease


Contraindications


Hypersensitivity to potassium p-aminobenzoate or any component of the formulation; concurrent use of sulfonamides


Dosing and Administration


Dosing: Adult

Oral: Average dose: 12 g/day in 4-6 divided doses


Dosing: Geriatric

Refer to adult dosing.


Dosing: Pediatric

Oral: 1 g/10 pounds of weight/day; administer in divided doses


Dosing: Renal Impairment

No dosage adjustment provided in manufacturer 's labeling. Use with caution.


Dosing: Hepatic Impairment

No dosage adjustment provided in manufacturer 's labeling.


Administration

All forms should be administered after meals or with a snack.

Capsule: Take with a glass of water.

Tablet: Crush and add to glass of chilled water or juice; stir and drink.


Dietary Considerations

Take with food to avoid stomach upset.


Dosage Forms/Strengths


Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

M2 Potassium: 60 mg [DSC]

Potaba: 500 mg

Packet, Oral:

Generic: 2 g (50 ea)

Tablet, Oral:

Potaba: 500 mg [DSC]


Drug Interactions

Sulfonamide Derivatives: Potassium P-Aminobenzoate may diminish the therapeutic effect of Sulfonamide Derivatives. Avoid combination


Adverse Reactions


Frequency not defined.

Central nervous system: Fever

Dermatologic: Rash

Gastrointestinal: Anorexia, nausea

Miscellaneous: Hypersensitivity reaction


Warnings/Precautions


Concerns related to adverse effects:

- Anorexia: Interrupt therapy if anorexia occurs; may reinstitute once patient improves.

- Nausea: Interrupt therapy if nausea occurs; may reinstitute once patient improves.

Disease-related concerns:

- Diabetes: Use with caution in patients with diabetes mellitus or a history of hypoglycemia.

- Renal impairment: Use with caution in patients with renal impairment.


Pregnancy Considerations

Safety for use in pregnancy has not been established.


Actions


Pharmacology

P-aminobenzoate is a member of the vitamin B complex family. It may have an antifibrotic effect due to increased oxygen uptake at the tissue level.


Patient and Family Education


Patient Education

- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

- Have patient report immediately to prescriber lack of appetite or nausea (HCAHPS).

- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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