(IP e kak SIR up)
Treatment of acute oral drug overdosage and in certain poisonings
Hypersensitivity to ipecac or any component of the formulation; do not use in unconscious patients; patients with no gag reflex; following ingestion of strong bases, acids, or volatile oils; when seizures are likely
Emetic: Oral: 15-30 mL followed by 200-300 mL of water; repeat dose one time if vomiting does not occur within 20 minutes.
Refer to adult dosing.
Emetic: Oral:
6-12 months: 5-10 mL followed by 10-20 mL/kg of water; repeat dose one time if vomiting does not occur within 20 minutes.
1-12 years: 15 mL followed by 10-20 mL/kg of water; repeat dose one time if vomiting does not occur within 20 minutes.
Note: If emesis does not occur within 30 minutes after second dose, ipecac must be removed from stomach by gastric lavage.
Do not administer to unconscious patients. Patients should be kept active and moving following administration of ipecac. If vomiting does not occur after second dose, gastric lavage may be considered to remove ingested substance.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Syrup, oral: USP: 7% (30 mL [DSC])
Frequency not defined.
Cardiovascular: Cardiotoxicity
Central nervous system: Lethargy
Gastrointestinal: Diarrhea, protracted vomiting
Neuromuscular & skeletal: Myopathy
Disease-related concerns:
- Bulimia: Use with caution in patients with bulimia.
- Cardiovascular disease: Use with caution in patients with cardiovascular disease.
Other warnings/precautions:
- Product confusion: Do not confuse ipecac syrup with ipecac fluid extract, which is 14 times more potent.
Other warnings/precautions:
- Antiemetic overdose: May not be effective in antiemetic overdose.
C
Irritates the gastric mucosa and stimulates the medullary chemoreceptor trigger zone to induce vomiting
Significant amounts, mainly when it does not produce emesis
Urine; emetine (alkaloid component) may be detected in urine 60 days after excess dose or chronic use
15-30 minutes
20-25 minutes; 60 minutes in some cases