(KROE moe lin)
Prophylactic agent used for long-term (chronic) control of asthma; prevention of exercise-induced bronchospasm
Hypersensitivity to cromolyn or any component of the formulation
Asthma: Nebulization solution: Initial: 20 mg 4 times/day; usual dose: 20 mg 3 to 4 times/day
Note: For chronic control of asthma, taper frequency to the lowest effective dose (ie, 4 times/day to 3 times/day to twice daily). Not effective for immediate relief of symptoms in acute asthmatic attacks; must be used at regular intervals for 2 to 4 weeks to be effective.
Prophylaxis of bronchospasm (allergen- or exercise-induced): Nebulization solution: 20 mg (single dose), administer 10 to 15 minutes prior to exercise or allergen exposure
Refer to adult dosing.
Asthma: Children >2 years and Adolescents: Refer to adult dosing.
Prevention of allergen- or exercise-induced bronchospasm: Children >2 years and Adolescents: Refer to adult dosing.
There are no dosage adjustments provided in manufacturer 's labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in manufacturer 's labeling. However, dosage adjustment unlikely due to low systemic absorption.
Oral inhalation: Squeeze contents of the unit-dose vial into the solution container of nebulizer. Nebulization should take approximately 5 to 10 minutes.
Store at room temperature of 15 ‚ °C to 30 ‚ °C (59 ‚ °F to 86 ‚ °F). Protect from light.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Nebulization Solution, Inhalation, as sodium:
Generic: 20 mg/2 mL (2 mL)
Nebulizer solution is compatible with metaproterenol sulfate, isoproterenol hydrochloride, 0.25% isoetharine hydrochloride, epinephrine hydrochloride, terbutaline sulfate, and 20% acetylcysteine solution for at least 1 hour after their admixture.
There are no known significant interactions.
Periodic pulmonary function tests
Frequency not always defined.
Central nervous system: Drowsiness
Dermatologic: Burning sensation of the nose, pruritus of nose
Gastrointestinal: Nausea, stomach pain
Hypersensitivity: Serum sickness
Respiratory: Cough (20%; transient), wheezing (4%; mild), epistaxis, nasal congestion, sneezing
<1% (Limited to important or life-threatening): Anaphylaxis, anemia, dysuria, exfoliative dermatitis, hemoptysis, hoarseness, lacrimation, laryngeal edema, nephrosis, myalgia, parotid gland enlargement, vasculitis (periarteritis), pericarditis, peripheral neuritis, photodermatitis, polymyositis, pulmonary infiltrates (with eosinophilia), vasculitis (periarteritis)
Concerns related to adverse effects:
- Anaphylaxis: Severe anaphylactic reactions may occur rarely
- Bronchospasm: May occur with cough after inhalation; if this occurs, treat with a fast-acting bronchodilator.
Disease-related concerns:
- Asthma: Not to be used in the treatment of status asthmaticus.
Other warnings/precautions:
- Withdrawal: Caution should be used when withdrawing the drug or tapering the dose as symptoms may reoccur.
B
Adverse events were not observed in animal reproduction studies. No data available on whether cromolyn crosses the placenta or clinical effects on the fetus. Available evidence suggests safe use during pregnancy.
Prevents the mast cell release of histamine, leukotrienes, and slow-reacting substance of anaphylaxis by inhibiting degranulation after contact with antigens
Inhalation: ~8% reaches lungs upon inhalation; well absorbed
Equally excreted unchanged in urine and feces (via bile); after inhalation, small amounts are exhaled
Serum: Inhalation: ~15 minutes
80 to 90 minutes
- Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
- Patient may experience diarrhea, headache, sneezing, or bad taste. Have patient report immediately to prescriber difficulty breathing or persistent cough (HCAHPS).
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.